Preliminary Study on the Immunostimulatory and Antitumor Mechanisms of Dictyophora Polysaccharides
DOI:
https://doi.org/10.67206/qzvaff68Keywords:
Dictyophora polysaccharides, immune cells, proliferation, antitumor, myeloid-derived suppressor cells (MDSCs)Abstract
This study aims to investigate the immunostimulatory and antitumor effects of Dictyophora polysaccharides and preliminarily analyze their effects on myeloid-derived suppressor cells (MDSCs). An in vitro cell culture approach was employed to evaluate the immunoproliferative and tumor-killing effects of Dictyophora polysaccharides. Additionally, the effects on MDSCs in the spleen of tumor-bearing mice were observed to explore the potential mechanisms underlying the antitumor immune response. The results showed that Dictyophora polysaccharides enhanced both cellular and humoral immunity, promoting the proliferation of CD4+, CD8+, and B cells in a dose-dependent manner. In T-cell-mediated tumor cell-killing assays, Dictyophora polysaccharides did not directly enhance the tumor-killing activity of immune cells. However, Dictyophora polysaccharides demonstrated a trend of reducing the proportion of MDSCs. These findings suggest that Dictyophora polysaccharides enhance the proliferation of immune cells and may exert antitumor effects by decreasing the proportion of immunosuppressive MDSCs.
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