Study on the Antitumor Effects of Crude Polysaccharides from Bamboo Fungi in Guizhou and Anhui Provinces
DOI:
https://doi.org/10.67206/ygn9xa53Keywords:
Crude polysaccharides from Dictyophora indusiata, Polysaccharides with antitumor activity, Cancer-associated fibroblasts (CAFs)Abstract
This study aimed to compare the inhibitory effects of crude polysaccharides extracted from Dictyophora indusiata sourced from Guizhou and Anhui provinces on tumor cells in vitro and their stimulatory effects on cancer-associated fibroblasts (CAFs) to evaluate the antitumor efficacy of these polysaccharides. Tumor cell growth was assessed using CCK and MTT assays as well as a real-time label-free cell analysis system. The cytotoxicity of crude polysaccharides on tumor cells was examined using flow cytometry, and the inhibitory effects on CAF growth were preliminarily evaluated. The results revealed regional differences in the antitumor effects of crude polysaccharides from D. indusiata and demonstrated that these polysaccharides could inhibit the proliferation of CAFs.
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